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ea0081ep509 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Is Semaglutide superior than Liraglutide in patients with type 2 diabetes on insulin therapy? - case presentation

Mickovski Ivana , Buklioska-Ilievska Daniela , Milosheska Radmila , Hasan Taner

Type 2 diabetes (T2DM) is a chronic and progressive disease associated with microvascular and macrovascular complications leading to increased morbidity and mortality. Insulin remains the cornerstone therapy for longer-duration T2DM and b-cell failure. Glucagon-like peptide-1 receptor agonists are a class of multifactorial T2DM medications that have been shown to improve numerous risk factors for diabetes-related complications, including glycemic control, reduction in body wei...

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ea0070aep92 | Adrenal and Cardiovascular Endocrinology | ECE2020

Cystic pheochromocytoma, a diagnostic challenge: A case report

Volkanovska Ilijevska Cvetanka , Hasan Taner , Malinovska-Nikolovska Liljana , Krstevska Brankica , Volkanovska Nikolovska Ance

We describe a case of cystic pheochromocytoma (PCC) with negative biochemical evaluation, diagnosed on the basis of hypertensive crises during operative management and histopathologic findings. A 57-year-old woman complained of several episodes of stabbing right upper abdominal pain accompanied by tachycardia, headache, lack of breath, elevated blood pressure and vomiting in the preceding three years. At presentation, blood investigations were significant only for mildly eleva...

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ea0070aep268 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association of the APOEgene polymorphism with diabetic nephropathy

Hasan Taner , Josifovska Slavica , Trajkovska Ivana , Doneva Daniela , Nedeska Natasha , Volkanovska Ilijevska Cvetanka

The protein isoformes that are products of the Apolipoprotein E (APOB) gene polymorphism have partially altered biological activity and that may lead to greater susceptibility of the patientsto microvascular complications including Diabetic nephropathy (DN)in patients with the Type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate the association between the allele ε2, ε3, and ε4 of the APOE gene, as well as their combination, w...

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ea0073aep143 | Calcium and Bone | ECE2021

Postsurgical hungry bone syndrome in unrecognized severe primary hyperparathyroidism: A case report

Ilijevska Cvetanka Volkanovska , Zivkovic Marija , Stevchevska Aleksandra , Otovikj Natasha Eftimovska , Hasan Taner , Mishevska Sasha Jovanovska

Parathyroidectomy for hyperparathyroidism can be complicated with development of Hungry Bone Syndrome (HBS), a constellation of profound hypocalcemia with hypomagnesemia and hypophosphatemia. The severity of this potential life-threatening condition is related to the extent of the parathyroid-mediated high-turnover bone disease. We present a case of a 59-year-old woman developing post-surgical HBS as a result of longstanding severe unrecognized primary hyperparathyroidism (PHP...

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ea0073aep319 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Angiotensin-converting enzyme gene (i/d) polymorphism in association with the diabetic nephropathy

Hasan Taner , Trajkovska Ivana , Nedeska Natasha , Ilijevska Cvetanka Volkanovska , Josifovska Slavica

Polymorphisms in the Angiotensin-converting enzyme (ACE) gene have been associated with development of diabetic nephropathy (DN), a major microvascular complication of the type 2 diabetes mellitus (T2DM). Since the genetic predisposition plays an important role in development of DN in patients with T2DM, genetic testing might largely contribute to better assessment of the risk of DN in such patients. The aim of this study is to investigate the association of the ACE gene I/D p...